Avibodies

The AvibodyTM Platform

Avibodies consist of the key target binding domains of intact antibodies but in a compact format.

Avipep utilises proprietary conjugation sites on the Avibody surface which results in an exact Drug-Antibody Ratio (DAR) of two or four drugs per Avibody. This supersedes random conjugation which produces poor quality heterogeneous products with variable (DAR).


Advantages of Avibodies

  • Rapid generation from existing antibodies
  • High avidity
  • Site-specific conjugation
  • Efficient and rapid tumor penetration
  • Tuneable pharmacokinetics
  • Safety demonstrated in clinical studies


Phase I Clinical data

A Phase I clinical biodistribution trial using 124I-PEG-AVP04 and Positron-Emission Tomography (PET) imaging in prostate and ovarian cancer patients demonstrated excellent tumor uptake with no uptake in normal tissues. Rapid targeting of the tumor was observed in 24 hrs with high tumor load extending to over one week. The trial met all safety endpoints with no adverse events nor immunogenicity. Metastatic lesions in lymph nodes and liver were clearly identified and with clearance T½ beta ~ 44hrs the PEG-AVP04 demonstrated improved pharmacokinetics (PK) compared to intact antibodies.

The most notable results from the study include:

  • High stability of Avibodies in vivo for over one week
  • Higher tumor uptake, estimated to be at least 4 fold higher than intact antibodies
  • Faster whole-body clearance than intact antibodies

Taken together, these data demonstrate that Avibodies achieve a superior level of payload delivery to tumors which should translate into higher therapeutic efficacy, lower systemic toxicity and a greater therapeutic window when employed as Antibody drug conjugates (ADCs).